Modeling studies on the role of vitamins B1 (thiamin), B3 (nicotinamide), B6 (pyridoxamine), and caffeine as potential leads for the drug design against COVID-19Article Published on 2022-11-072022-11-15 Journal: Journal of molecular modeling [Category] SARS, 신약개발, 치료제, [키워드] ACE-2 adopted Antiviral antiviral activity applied approach binding pocket binding site caffeine Cell Characteristics chemical property Compound COVID-19 COVID-19 pandemic docking domain dosage drug design effective evaluate function impair Interaction Invasion lack mechanism modeling molecular molecular dynamic simulations Neutral nicotinamide potential mechanism Protein pyridoxamine Safe SARS-CoV-2 selected Side effects Structural analysis Structure the SARS-CoV-2 the Spike thiamin Toxicity Vitamin Vitamin B. [DOI] 10.1007/s00894-022-05356-9 PMC 바로가기
Long-term monitoring of drug consumption patterns during the COVID-19 pandemic in a small-sized community in Brazil through wastewater-based epidemiology폐수 기반 역학을 통해 브라질의 소규모 커뮤니티에서 Covid-19 Pandemic 동안 약물 소비 패턴의 장기 모니터링Article Published on 2022-09-012022-08-31 Journal: Chemosphere [Category] MERS, 바이오마커, 치료제, [키워드] Abuse affecting amphetamine Analysis Biomarker Brazil caffeine can be used cellular cellular phone closure cocaine Community complementary Consumption COVID-19 COVID-19 pandemic described drug epidemiological Epidemiology evaluated expressed followed by global public health health problem highest illicit drugs information Long-term monitoring MDMA methamphetamine negative correlation Nicotine P-value POCIS sampling polar reduced reduction in unemployment was used wastewater Wastewater-based epidemiology. [DOI] 10.1016/j.chemosphere.2022.134907 PMC 바로가기 [Article Type] Article
Impact of COVID-19 vaccine on epilepsy in adult subjects: an Italian multicentric experience성인 대상의 간질에 대한 COVID-19 백신의 영향: 이탈리아의 다심적 경험Observational Study Published on 2022-08-012022-09-11 Journal: Neurological Sciences [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] Administered administration Adult patients age alcohol caffeine Characteristics clinic Cohort confidence interval coronavirus COVID-19 COVID-19 vaccine COVID-19 vaccines defined demonstrated epilepsy expressed Focal seizure Frequency generalized epilepsy Impact increase in interview Italian medication Multivariate analysis Observational cohort study occurred Outpatient Participants participated Patient Post-vaccine pre-vaccination questionnaire receive recruited SARS-COV-2 infection Seizure Seizures short term Side effect significantly stability STABLE the patient the vaccine Tolerability treated Treatment two groups Vaccine vaccine. Variation worsening [DOI] 10.1007/s10072-022-06100-0 PMC 바로가기 [Article Type] Observational Study
Prospects of Coffee Leaf against SARS-CoV-2 InfectionSARS-COV-2 감염에 대한 커피 잎의 전망Article Published on 2022-07-112022-08-31 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), MERS, SARS, 변종, 치료제, [키워드] (alpha ACE2 acute respiratory syndrome Alpha Analysis Anti-SARS-CoV-2 Activity Beta caffeine Cell CGA chlorogenic acid Coffea Coffea Arabica coffee Coffee leaf Compound Concentration concern coronavirus country Delta demonstrated develop effective Effectiveness ELISA energy transfer Ethanol experiment Extract FIVE Gamma gelatin hand sanitizer host cells identify Infection inhibit inhibited leaf mangiferin mechanism membrane omicron pandemic Research respiratory SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome skin skin. spike spike-ACE2 spray Taiwan the SARS-CoV-2 TMPRSS2 Type was tested was used wild-type SARS-CoV-2 [DOI] 10.7150/ijbs.76058 PMC 바로가기 [Article Type] Article
Caffeine and caffeine-containing pharmaceuticals as promising inhibitors for 3-chymotrypsin-like protease of SARS-CoV-2SARS-COV-2의 3- 키모 트립신 유사 프로테아제에 대한 유망한 억제제로서 카페인 및 카페인 함유 제약.Article Published on 2022-03-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, 치료제, [키워드] 3-chymotrypsin-like protease 3CL pro active site active sites acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approved aqueous solution binding binding affinity bromotheophylline caffeine caffeine-containing pharmaceuticals catalytic chymotrypsin clinical trial Complexes conformation coronavirus coronavirus SARS-CoV-2 COVID-19 COVID-19 treatment demonstrated docked complex docked complexes drug Drug administration dyphylline free energy Free energy calculation Free energy calculations in silico in vitro in vivo inhibitor inhibitory effect istradefylline knowledge linagliptin molecular molecular dynamics Molecular dynamics simulation molecular dynamics simulations molecular dynamics. Molecular mechanics New coronavirus outbreak Pentoxifylline protease pulmonary disease ranged repurposing residue SARS-CoV-2 Seven severe acute respiratory syndrome Coronavirus shown stability surface area theophylline therapeutic Treatment [DOI] 10.1080/07391102.2020.1835732 PMC 바로가기 [Article Type] Article
Elevated coffee consumption is associated with a lower risk of elevated liver fibrosis biomarkers in patients treated for chronic hepatitis B (ANRS CO22 Hepather cohort)Article Published on 2022-03-012023-06-13 Journal: Clinical nutrition (Edinburgh, Scotland) [Category] B형 간염, [키워드] caffeine coffee France hepatitis B Liver fibrosis. [DOI] 10.1016/j.clnu.2022.01.016 PMC 바로가기
First surveillance of SARS-CoV-2 and organic tracers in community wastewater during post lockdown in Chennai, South India: Methods, occurrence and concurrence인도 남부 첸나이에서 폐쇄 후 지역 사회 폐수에서 SARS-CoV-2 및 유기물 추적자의 첫 번째 감시: 방법, 발생 및 동시성Article Published on 2021-07-152022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, [키워드] absence biochemical biochemical oxygen demand caffeine can be used Chain Reaction Chemical Chemical marker Chennai Clinical data collected Combination Community Concentration conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infected patients cycle cycle threshold dynamic range Efficiency enveloped virus Epidemiology filtration FIVE followed by hospital Indicator infected individual lockdown Occurrence oxygen oxygen demand pandemic plant polymerase chain reaction predicted proportion qRT-PCR Quantitative removal responsible RNA RNA copies SARS-CoV-2 sediment Sewage treatment Sludge solid phase South south India SPS SPSS study period supernatant Surveillance tendency threshold time interval Treatment Viral load virus wastewater Wastewater based epidemiology. [DOI] 10.1016/j.scitotenv.2021.146252 PMC 바로가기 [Article Type] Article
The importance of early use of beta blockers and gastric decontamination in caffeine overdose: A case reportCase Reports Published on 2021-07-012023-07-06 Journal: Australian critical care : official journal of the Confederation of [Category] SARS, [키워드] activated charcoal caffeine COVID-19 overdose SARS-CoV-2 β-blockers. [DOI] 10.1016/j.aucc.2020.09.007 PMC 바로가기 [Article Type] Case Reports
Possible Beneficial Actions of Caffeine in SARS-CoV-2SARS-CoV-2에서 가능한 카페인의 유익한 작용Review Published on 2021-05-222022-08-31 Journal: International Journal of Molecular Sciences [Category] SARS, 신약개발, 치료제, [키워드] Action addition adenosine airway airway smooth muscle angiotensin Angiotensin-converting enzyme Anti-inflammatory antiviral activity Awareness caffeine chymotrypsin complex Consumption COVID-19 COVID-19 pandemic domain drug Effect effective fatigue host cell host cells immunomodulator immunomodulatory effects IMPROVE in silico in vitro in vivo models increase Infection inhibiting inhibitor mechanism molecular molecular docking molecular dynamics Proteases receptor receptor antagonist Receptor-binding domain reduce reduce viral replication required SARS-CoV-2 smooth muscle specific treatment suggested Treatment Viral viral replication wakefulness [DOI] 10.3390/ijms22115460 PMC 바로가기 [Article Type] Review
Exploitation of polyphenols and proteins using nanoencapsulation for anti-viral and brain boosting properties – Evoking a synergistic strategy to combat COVID-19 pandemicReview Published on 2021-03-112023-06-16 Journal: International journal of biological macromolecules [Category] MERS, SARS, [키워드] caffeine Cocoa flavonoids lectins Nanoencapsulation quercetin [DOI] 10.1016/j.ijbiomac.2021.03.028 PMC 바로가기 [Article Type] Review